Would you add a DMARD such as methotrexate for a patient with GCA and partial response to tocilizumab but inability to taper prednisone below 10mg daily?
Alternatively would you change therapy entirely to upadacitinib and consider this a tocilizumab failure?
Answer from: at Academic Institution
This is a clinical scenario that comes up relatively frequently, but unfortunately, there is a lack of data to guide this decision, and both approaches are reasonable. On balance, methotrexate has been demonstrated to have a moderate effect with respect to steroid sparing and reducing relapses in GC...