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Would you add immunosuppression in ocular myasthenia gravis patients who are symptomatically well-controlled on pyridostigmine?

In light of the recent publication by Menon et al., PMID 39079067 regarding the risk of converting to generalized MG as related to use of immunosuppression.
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Do you think that early immunosuppression in patients with ocular MG reduces the risk of generalization of MG?

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1 Answer
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Neurology · University of Minnesota
Answered on · Updated on

This requires a shared decision-making approach with the patient because there is no right or wrong answer/choice. Although it has never been demonstrated in a placebo-controlled blinded study, I do believe (for years now) that low-dose prednisone can reduce the risk of generalization of ocular MG.

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