Would you consider 160 mg of Osimertinib as opposed to 80 mg for adenocarcinoma lung with leptomeningeal metastasis?

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What is the optimal dose of osimertinib for leptomeningeal disease with EGFR mutation?

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Medical Oncology · Hematology Oncology Medical Group of Orange County

Answered on

I have tried it in 1 patient but it did not work, unfortunately. But there is data to support use 80mg dose as well as 160mg dose.

There is an abstract from 2017 ASCO with 160mg dose: BLOOM study abstract or https://clinicaltrials.gov/ct2/show/NCT02228369

This is an article with 80mg dose: Standard-d...

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