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Would you consider a cycle of EP in a patient with good risk stage IIIB seminoma on BEP but with bleomycin omitted for cycle 3?

Bleomycin omitted due to asymptomatic decline in DLCO
1 Answer
Mednet MemberInvited Expert
Medical Oncology · Indiana University Simon Cancer Center
Answered on

There are many aspects to this question.

  1. Good risk stage II seminoma has a 90-99% cure rate. I presume he has had all 3 five day courses of the EP component and 6 of 9 weeks of bleomycin. An ECOG study from about 30 (!) years ago compared BEP X 3 versus 3 courses EP for all types and histologies of good risk disease. The C.R. rates were similar but higher relapse rate with EP X 3, resulting in about an 8% lower cure rate, which is why EP X 3 is not a recommended option for good-risk disease. Im...

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