Would you consider adding pembrolizumab to chemoradiation for locally advanced cervical cancer in a patient with cirrhosis (elevated bilirubin (<3x ULN) and mild LFT elevation), ascites, and signs of portal hypertension?

How does liver cirrhosis influence your decision to add immunotherapy to chemoradiation for cervical cancer?

• If they are well enough for definitive chemoradiation, I would include immunotherapy
• In general, I would not risk the possibility of immune-related hepatitis
• Other