Would you consider adjuvant radiation therapy for a grade 1 meningioma with an elevated Ki67?

An answer to this important question requires conjecture as well as additional details. Ki-67 has indeed in some studies been identified as a promising biomarker [Liu et al., PMID 32118704, Tjuatja et al., PMID 36448071, Chen et al., PMID 29624151], however not uniformly so [Jensen et al., PMID 29296341]. The role of Ki-67 in terms of adjuvant radiotherapy as well as its optimal threshold requires further definition. We are now unquestionably entering an era in which molecular signatures will be...