In a patient with unresectable, multifocal recurrent cutaneous squamous cell carcinoma and underlying T-cell large granular lymphocytic leukemia with baseline moderate pancytopenia, is anti-PD-1 therapy (e.g., cemiplimab) an appropriate and safe treatment option?

This is a complicated question!

First, be sure of the diagnosis. The differential diagnosis is quite long. If it is something else that may or may not influence your decision.

Second, if we agree that the lesions are not resectable, might they be treated with radiation therapy? This will not give th...