Would you consider antiphospholipid syndrome to be a contraindication for checkpoint inhibitor immunotherapy?

Checkpoint inhibitor therapy is usually an important treatment for patients with advanced malignancy, and has greatly improved the prognosis of otherwise untreatable cancers, so I would not automatically proscribe these drugs because of a history of APS. I would ensure patients with APS are on full ...

While there have been several cases of antiphospholipid antibody syndrome (APS) induced by immune checkpoint inhibitor therapy (Gupta et al., PMID 28099367, Tota et al., PMID 34411840, Mintjens-Jager et al., PMID 33224503), I am unaware of any evidence that pre-existing APS contributes to additional...