I typically do not use a post-operative boost in patients with soft tissue sarcoma that have received preoperative radiation for a few reasons:(1) By the time surgery has happened and the patient has healed, it may be 2 months or more since completion of preoperative RT. If there is truly residual v...

I agree in general with @Anusha Kalbasi. I would also ask the surgeon to re-resect this patient if possible, assuming the positive margin is not on a critical/unresectable structure.  As Dr. Kalbasi describes, there are two negative postop boost studies in STS. However, there are some nuan...