Would you consider hormone replacement therapy in young women with germline BRCA1 mutation and history of triple negative breast cancer who underwent bilateral mastectomy and prophylactic bilateral salpingo-oophorectomy?

There is inadequate data to clearly answer the question of safety of HRT after a diagnosis of breast cancer. A recent review by Ugras and Rahman summarized the published literature and concluded that the evidence does not suggest an increase in recurrence or death with the use of HRT in this setting...

I agree with previous responses on this topic. Generally speaking, I would suggest alternative non-hormonal choices to treat menopausal symptoms in women with prior BC diagnosis. While initial observation studies were reassuring, the two Scandinavian RCTs (HABITS, STOCKHOLM) showed concern for incre...