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Would you consider PD-L1 score when deciding whether to incorporate durvalumab in first-line metastatic biliary cancer?

If so, what assay would you use in this population? Do we have data on TMB/PDL1 status of long-term survivors?
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Do you utilize biomarker/molecular testing for advanced biliary tract cancers?

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2 Answers
Mednet Member
Mednet Member
Medical Oncology · Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Answered on

There are no biomarkers that I currently recommend to select patients for durvalumab in first-line metastatic biliary cancer. In subgroup analysis, there appears to be benefit to durvalumab in first-line metastatic biliary tract cancer regardless of PDL1 expression. Therefore, I would not consider P...

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Mednet Member
Mednet MemberInvited Expert
Medical Oncology · University of Texas MD Anderson Cancer Center
Answered on

I do not, no clear benefit shown based on PDL1 status.

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