Would you consider prescribing a JAK inhibitor for a patient with a history of DVT who is on chronic anticoagulation, or would the thrombotic risk deter you?  

There is no definitive answer here except to say that most rheumatologists would likely explore and employ all other available options prior to selecting the higher-risk one in this type of patient. But, ultimately, if all other options were exhausted and unsuccessful, you still have a patient with ...