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Would you consider radiotherapy for unresectable malignant pleural mesothelioma in an asymptomatic patient?

In a non-surgical candidate, would you consider adding radiotherapy sequenced with chemotherapy at any point? Or do you reserve it for palliative purposes only? If so, what volume and dose? NCCN guidelines say to consider RT for Stage I-IIIA disease, but do not give further guidance.
1 Answer
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Radiation Oncology · University of Texas MD Anderson Cancer Center
Answered on

The standard of care is palliative chemotherapy + potential Ipi/Nivo now that there is that option. Radiation should be reserved for consolidation or palliation for symptomatic sites of disease or progression. Radiation should be done using hypofractionated approach, with dose per fraction exceeding...

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