Would you consider retrying a platinum based chemotherapy agent in a platinum resistant ovarian cancer patient?

3 Answers

Mednet Member

Medical Oncology · University of Utah School of Medicine

Yes, I would consider the use of platinum agent again, especially if it has been a long time since their last platinum therapy. I could consider the use of Cisplatin in this case or Carboplatin.

The GCOG consensus statement recommends the following timelines for platinum response classifications:

(1) ...

Mednet Member

Medical Oncology · University of Pittsburgh Magee Womens Hospital

Yes, definitely.

There are several case series showing a good response rate of weekly carbo (AUC2) and paclitaxel (60mg/m2) (one of several refs here). Anecdotally, we have excellent responses with minimal risk of toxicity using this regimen. There is also data from MSKCC that patients with platinum ...

Mednet Member

Gynecologic Oncology · Yale School of Medicine

Yes, I would consider retrying a platinum in combination with another agent.

In particular, I have had good anecdotal success with cis/cytoxan in this population (especially with BRCA deleterious mutation).