I would not use short course in the postoperative setting. Virtually all of the data on short course are preoperative, where most of the irradiated bowel is removed surgically. The patient would get over the acute reaction from short course postoperatively, but I have major concerns about late effec...

While I am not aware of any prospective data to support this, it is something worth considering in the current environment. I do have my own anecdotal experience suggesting some efficacy for this regimen, although the acute toxicity may be greater (just my experience). I have had a substantial numbe...