Would you consider starting immunotherapy concurrently with whole brain radiation for newly diagnosed metastatic (BRAF negative) melanoma with multifocal symptomatic brain metastases?

This is a challenging clinical situation. In part, the approach depends on the number and size of the CNS lesions. However, I do not recommend the use of WBRT for my patients, as it has not demonstrated a survival benefit. In addition, in the adjuvant trial comparing WBRT to observation, it did not ...

Generally I would agree with @Dr. First Last about the treatment of patients with BRAF wild type melanoma and brain metastases who do not require steroids or can be weaned quickly from them. I am not aware of data about concurrent use of immunotherapy (IO) and whole brain radiation therapy (WBXRT) t...