Would you consider using a JAK inhibitor for a patient with RA associated scleritis?

Yes, I have used it before with success when with limited options. I recommend speaking to the MSL from one of the JAKi developers and they can provide the data to make an informed decision or to appeal to insurance if denied.

Absolutely, especially when the patient failed TNF and actemra, has contraindication to rituxan. Just not sure what +test here for JC virus.