Would you consider using adjuvant chemotherapy for a patient with anal squamous cell carcinoma with a positive surgical margin after APR done for persistent/progressive disease after chemoradiotherapy?  

There is no evidence that postoperative chemotherapy can alter the negative prognostic significance of a positive surgical margin after APR and improve long-term outcomes. Consequently, I would monitor this patient closely and initiate treatment only when warranted by clinical and/or radiographic pr...