Would you consider using LDRT for joint pain/arthritis caused by aromatase inhibitors as a means to keep patients on therapy?

I would try this. I think there is an inflammatory component to this, and the subjective complaints appear to mimic OA.

However, I do think this would be a wonderful group of patients to try this on. They are probably already comfortable with radiation, the achiness/discomfort from ET is real and we hear about it a lot and the potential treatment is atoxic at 3 Gy in 6 Fx. In my experience, I have had no toxicity, save for 1-2 % of patients experiencing a brief, self-limited pain flare.

I do bel...

I have not offered LDRT for this given no data, but this would be an excellent scenario to consider for prospective evaluation even in a single-arm ph II setting as proof of concept.