Would you continue consolidation temozolomide for more than 1 year for a patient with grade 3 anaplastic astrocytoma, after gross total resection and daily temozolomide+EBRT?

Thank you for the question.

The short answer is, "no". There is no data that adjuvant chemotherapy beyond 12 months improves outcomes. The temozolomide is usually very well tolerated, but it is associated with bone marrow injury with myelodysplasia or leukemia as risks. So, in general with no upside,...