Would you continue to monitor urinary protein levels and dose adjust axitinib in a patient with metastatic malignancy who is now dialysis dependent but has residual renal function?  

The question lacks specificity, so I will assume that this refers to a patient with irreversible ESRD not due to the TKI itself. Generally, if the proteinuria was exclusively due to the TKI, the HTN and proteinuria will abate when the drug is discontinued. Also, as renal function declines, the pro...