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Topics:
Gynecologic Cancers • Ovarian Cancer
Would you ever re-treat recurrent ovarian cancer with mirvetuximab soravtansine if the patient responded to it in the past (e.g., more than 6 months ago)?
What is your general philosophy when discontinuing and/or switching chemotherapy in the recurrent setting?
Answer from: at Academic Institution
As far as I know, there is no data on the repeat use of mirvetuximab for women who have progressed on prior treatment. I would tend to use cytotoxic therapy in this setting, but if the patient tolerated it well previously and has a good performance status, a short trial of repeat mirvetuximab seems ...
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Answer from: at Community Practice
Agree with Dr. @Chu. Discontinuation due to progression is probably different from discontinuation due to other events, especially if there was documentation of response. I have personally retreated patients with FRa high expression with mirvetuximab and discontinued treatment due to some intoleranc...