Ovarian Cancer   

Questions discussed in this category



Genes such as ATM, CHEK2, PALB2, RAD51C/D, BRIP1 seem to show some potential increased risk of ovarian cancer. Should these patients under prophylacti...

For a young patient that underwent fertility sparing surgery for immature teratoma of the ovary, would you treat until tumor markers normalize even if...

Is there any role for completion surgery and/or RT in addition to chemotherapy? 12cm mass on ovary s/p TH/USO and preservation of grossly normal cont...

Excellent KPS and long disease free interval from initial diagnosis. Initial recurrence 3-4cm at level of renal vessels and down to 1.3cm after chemo.

s/p optimal debulking. If this was an early-stage cancer would it change your adjuvant therapy recommendations?

Recurrence picked up incidentally on CT. No germ line mutations, somatic tumor testing of node resulted negative. PET confirmed isolated recurrence

Presented with 8cm pelvic mass and had large omental cake + significant carcinomatosis on diagnostic lap. Biopsy ultimately resulted non-epithelial ov...

Does your practice vary based on risk status (low vs high risk) or specific mutation status (BRCA+ vs HRD+) given PAOLA subset analyses? 

What specific platforms for determining somatic BRCA and HRD status do you use for a patient who does not carry a germline BRCA mutation?

Primary R0 debulking in 2018 followed by Carbo/Tax for 6 cycles, and single agent Bevacizumab followed by Letrozole, now again with NGR

Given recent approval of niraparib (Zejula) for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or prima...

Would you change your approach based on platinum sensitivity or other factors?

EP vs C/T? Would you perform additional imaging, ie. PET Dotatate to evaluate for metastatic disease?

Most interested in patient cohorts who have not demonstrated a good response to chemotherapy as measured by imaging and/or clinical/serological findin...

 Specifically, if they are to be treated similar to GI cancers that receive FOLFOX/EPIC

Would you approach this situation as synchronous primaries (eg. FIGO IA in both) or as a locally advanced endometrial cancer (FIGO IIIA)? What adjuva...

For example, would you consider adjuvant chemotherapy alone to be sufficient in a patient with an isolated pelvic recurrence and positive margin after...


Papers discussed in this category


Gynecologic oncology, 2013-08

J Clin Oncol, 2012 May 10

Ann. Oncol., 2011-02-01

Gynecologic oncology, 2010-03

Cancer, 1987-10-15

Gynecologic oncology, 2015-09

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-06-10

Lancet Oncol, 2017 Jun

Lancet (London, England), 2017-10-28

The New England journal of medicine, 2016-12-01

The New England journal of medicine, 2012-04-12

The Lancet. Oncology, 2017-09

J. Clin. Oncol.,

Gynecologic oncology, 2019-06

N. Engl. J. Med., 2019 Sep 28

N Engl J Med, 2019 Dec 19

The New England journal of medicine, 2011-12-29

The New England journal of medicine, 2006-01-05

Lancet Oncol, 2013 Sep

N Engl J Med, 2011 Dec 29

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-06-01

J. Clin. Oncol., 2019 Apr 19

N Engl J Med, 2016 Feb 25

The New England journal of medicine, 2018-12-27

Gynecologic oncology, 2018-12

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-09-10

Br. J. Cancer, 2009 Feb 17

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2011-05

Obstet Gynecol,

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-04-01

Gynecol. Oncol., 2017 Jul 30

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000-01

Lancet, 2019 Nov 29

Lancet Oncol., 2014 Feb 28

Lancet,

Gynecologic oncology, 2009-08

Lancet Oncol.,

Br. J. Cancer, 2018 Oct 24

Clinical cancer research : an official journal of the American Association for Cancer Research, 2018-02-15

N Engl J Med, 2019 Dec 19

J Clin Oncol, 2020 Apr 10

N. Engl. J. Med.,

Journal of robotic surgery, 2019-02

Am. J. Obstet. Gynecol., 2015 Oct 31

Obstet Gynecol,

Gynecologic oncology, 2015-12

The American journal of surgical pathology, 2015-04

The American journal of surgical pathology, 2006-02

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2013-11

Gynecologic oncology, 2017-07

J Ovarian Res, 2019 May 25

Oncologist, 2019 May

Am. J. Surg. Pathol.,

Int J Gynaecol Obstet, 2013 Oct 22

Ann Oncol,

PLoS One, 2017 Sep 05

Oncology, 2016 Oct 27

Gynecol Oncol, 2013 Dec 09

Ann Surg Oncol, 2013 Sep 20

Gynecol Oncol, 2014 Sep 16

Arch Gynecol Obstet, 2016 Dec 03

J Clin Oncol, 2014 May 1

The Lancet. Oncology, 2017-01

The Lancet. Oncology, 2019-05

Journal of the National Comprehensive Cancer Network : JNCCN, 2016-09

Human pathology, 2000-05

Eur J Cancer, 2013 May

Virchows Arch, 2016 Dec 27

Gynecol Oncol, 2015 Jul 29

Oncologist, 2012 Sep 28

Int J Cancer,

J Clin Oncol, 2015 Sep 28

Gynecol Oncol, 2020 Jan 20

Gynecol Oncol, 2011 Sep 13

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 2015-01

Am J Surg Pathol,

The New England journal of medicine, 2018-11-01

Gynecologic oncology, 2008-03

Lancet Oncol, 2021 Mar 18

Lancet Oncol, 2015 Jun 23

Cancer, 2014-02-01

Tumori, 2016 May 09

Gynecol Oncol, 2019 Jun 10

Gynecol Oncol, 2020 Jan 15

Gynecol Oncol, 2016 Oct 10

J Obstet Gynaecol, 2017 Aug 07

Gynecologic oncology, 2016-01

Gynecol Oncol, 2020 Jul 9

Gynecol Oncol, 2020 Jul 25

N Engl J Med, 2021 Jun 03

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2014-11