Gynecologic Cancers   

Questions discussed in this category

Are there scenarios that new visits/consults with patients can be done virtually amidst the COVID-19 outbreak?
6 Answers available
Would you consider modifying T&O fractionation during the COVID-19 pandemic?
What dose/fractionation would you recommend?
2 Answers available
With COVID-19 worries, are you more likely to offer women with endometrial cancer vaginal cuff brachytherapy over EBRT?
1 Answer available
How should you manage a coronavirus infected/suspected patient who is receiving radiotherapy and cannot interrupt or delay their cancer treatment?
How would you approach a patient who is receiving chemoRT but has confirmed COVID-19 with minor symptoms, as breaking treatment for 2 weeks quarantine...
7 Answers available
What are the current official guidelines regarding managing patients during COVID-19?
3 Answers available
What clinical factors would lead to utilizing a tandem and cylinder rather than tandem and ovoid for cervical cancer brachytherapy?
3 Answers available
What is the longest acceptable interval between hysterectomy and VCBT for HIR EMCA in the age of COVID-19?
2 Answers available
How do you manage bladder fullness during cervical T&O brachytherapy to minimize OAR dose?
Small bowel is usually the dose limiting OAR while planning cervical HDR brachytherapy. Having the bladder empty during treatment planning and deliver...
2 Answers available
Should I wear gloves during a routine physical exam on an asymptomatic patient with no risk factors for COVID-19?
1 Answer available
What measures should we take regarding routine follow-up visits for well patients in surveillance during the coronavirus pandemic?
When a physical exam is important and telehealth is not a good option, should we be proactive and reschedule or should we continue to see them as sche...
2 Answers available
In a patient metastatic recurrent endometrioid endometrial cancer who has a mixed response to carboplatin and paclitaxel, what is your next choice of therapy?
 No adjuvant treatment was given upfront
1 Answer available
Do you consider MSI testing for nonserous ovarian cancer?
1 Answer available
What would you recommend for early stage vulvar cancer with close margins?
Sentinel Lymph Nodes negative
2 Answers available
What techniques do you use to address fertility preservation in young female patients being treated with chemoradiation therapy for cancer in the pelvis?
How do you prevent early menopause in women? Please comment on freezing of eggs, oophopexy, supine vs prone position, vaginal dialator. 
4 Answers available
What are your next steps in management for a patient with endocervical adenocarcinoma s/p radical trachelectomy with a positive pelvic lymph node noted on final pathology?
Margins are negative.
1 Answer available
What treatment would you offer a patient with metastatic cervical cancer to the supraclavicular nodes with a complete clinical response in her nodes, but a 3 cm residual in the cervix?
1 Answer available
Is there a role for IP chemotherapy in advanced mucinous ovarian cancers following complete cytoreductive surgery?
 Specifically, if they are to be treated similar to GI cancers that receive FOLFOX/EPIC
1 Answer available
What is your process for obtaining and using next generation sequencing on patients with advanced endometrial cancer?
1 Answer available
How do you approach ITCs in sentinel lymph node biopsy in a vulvar cancer patient?
2 Answers available
What intracavitary brachytherapy regimen would you use after EBRT for a 4cm vaginal leiomyosarcoma the mid vagina with positive margins?
MRI with intravaginal gel shows no gross residual disease.
2 Answers available
In a patient with a vaginal cuff recurrence from endometrial cancer not amenable to interstitial brachytherapy, how would you boost after 45Gy?
Insurance authorization for protons is pending, but if the patient cannot have protons would you treat with standard fractionation to ~70Gy or conside...
1 Answer available
How do you decide the right time to transition to hospice?
Obviously, patient and caregiver preferences are paramount. But, what factors do you consider? Does expanded hospice (e.g., Medicare Care Choices) inf...
3 Answers available
In what situations would you perform a sentinel lymph node biopsy for cervical cancer?
1 Answer available
When, if ever, would you recommend hysterectomy after chemoradiation for patients with locally advanced cervical cancer?
This has been a common practice in the community. Is there a benefit for certain patients?
2 Answers available
What adjuvant chemotherapy is preferred in primary ovarian mucinous adenocarcinoma of intestinal type?
2 Answers available
What rectal dose constraints do you use for definitive chemoradiation for vulvar/vaginal cancer?
1 Answer available
In a surgically staged Stage II Grade 1 endometrial adenocarcinoma, with no other high risk factors, would you treat with brachytherapy alone or add on the pelvic RT?
NCCN recommends brachytherapy plus or minus pelvic RT for surgically staged Grade 1, Stage II patients, but these originally staged IIB patients were ...
4 Answers available
Would you recommend radiotherapy for a para-aortic recurrence of endometrial cancer in a patient who previous completed surgery, chemotherapy, and WPRT?
1 Answer available
Would you consider retrying a platinum based chemotherapy agent in a platinum resistant ovarian cancer patient?
3 Answers available
Is there a role for definitive radiation in a patient with vaginal melanoma who is not a surgical candidate?
What fields would you cover and how much dose would you boost to the primary?
1 Answer available
Do you routinely discuss HRT with patients that have undergone surgical menopause due to treatment of cervical cancer?
1 Answer available
Would you consider IP chemotherapy in a BRCA positive advanced ovarian cancer patient after upfront ovarian debulking surgery to no gross residual?
2 Answers available
What is the role of consolidation chemo in Stage IIIB cervical cancer s/p chemoRT?
1 Answer available
Would you recommend radiation for micrometastasis on sentinel lymph node biopsy in otherwise low risk endometrial cancer?
1 Answer available
Should a bowel prep be considered when performing an ovarian cancer debulking and/or bowel resection?
2 Answers available
How does the presence of microcystic elongated and fragmented (MELF) invasion impact post operative treatment of Stage IA FIGO grade 1 endometrial cancer?
1 Answer available
Given the final results of GOG258, what regimen do you recommend use to treat Stage III endometrial cancer?
Since there is no overall survival benefit, does the local control benefit outweigh the increased risk for distant metastasis? How do you select patie...
2 Answers available
How do you explain progression free survival to patients?
5 Answers available
How would you approach an inoperable, elderly, frail patient with high risk endometrial cancer?
1 Answer available
How would you treat an endometrial cancer with pelvic sidewall nodes, patient s/p TAH/BSO but nodes were fixed and unresectable?
Would you consider EBRT or brachytherapy boost to the nodes? what dose would you recommend?
2 Answers available
What is your approach to managing patients with medically inoperable early stage endometrial adenocarcinoma who also cannot tolerate intracavitary brachytherapy (Rotte-Y, etc) as boost?
3 Answers available
For an non-operative patient with IB1 cervical cancer, would you recommend RT alone or concurrent chemoRT for definitive therapy?
2 Answers available
When would you consider radiation for a Sertoli-Leydig tumor of the ovary with a bulky mass and peritoneal metastases after surgery and BEP chemotherapy?
What field and dose would you recommend? Would you consider whole abdominal? 
2 Answers available
When do you use a vaginal cuff boost with pelvic RT for stage II endometrial cancer?
For the management of stage II endometrial cancer, NCCN says pelvic RT and/or vaginal brachytherapy.   Do you ever add vaginal cuff boost to pelv...
3 Answers available
Would you offer adjuvant radiation to a patient with uterine undifferentiated sarcoma s/p resection, vaginal cuff recurrence, and re-resection?
If so, would you treat the whole pelvis, cuff brachytherapy, or both?
2 Answers available
Would you consider radiation therapy for ovarian dysgerminoma with residual lymphadenopathy after chemotherapy?
1 Answer available
Does the presence of a POLE mutation in endometrial cancer guide your recommendations regarding adjuvant radiation?
1 Answer available
Can you omit the vulva from the radiation field in isolated LN recurrence several years after initial vulvectomy/nodal dissection without adjuvant RT?
The patient had an initial partial vulvectomy and nodal dissection 6 years prior to recurrence, with no adjuvant RT offered initially due to lack of c...
2 Answers available
How would you approach a young patient with a locally advanced endometrial cancer with cervical involvement and a solitary bone metastasis?
2 Answers available
What alternative boost methods (techniques / dose) do you recommend for a vaginal cuff boost after whole pelvis when imaging shows bowel adherent to the vaginal cuff?
1 Answer available
How successful is IVF after definitive radiation therapy to the pelvis for endometrial cancer?
How do you counsel a pre-menopausal female with endometrioid cancer desiring definitive RT with egg harvesting and IVF for fertility preservation inst...
2 Answers available
How would you manage a small posterior vaginal defect noted at the time of cervical brachytherapy?
Patient being treated for cervical cancer noted to have a < 1 cm posterior vaginal fornix defect with a small focus epiploclia herniating into the ...
2 Answers available
Would the findings of a synchronous T1a ovarian endometrioid adenocarcinoma affect your treatment recommendation for a IB, G2 uterine endometrioid adenocarcinoma and LVSI?
2 Answers available
Do you routinely offer PARP inhibitor maintenance therapy to germline BRCA1/2+, FIGO stage II serous ovarian carcinoma patients after first line chemotherapy?
SOLO1 trial studied stage 3/4 patients.
1 Answer available
Would there be any contraindication to whole pelvic RT for a patient with an ax-bifem bypass & the graft crosses the lower abdomen within the RT field?
Would you recommend any planning techniques or dosimetric constraints in this scenario?
1 Answer available
Would you recommend adjuvant radiation for well-differentiated gastric-type adenocarcinoma of the cervix, stage 1b without LVI?
The limited data on MDA (minimum deviation adenocarcinoma) suggests it has a worse prognosis, but it is hard to disentangle this from stage, as it is ...
1 Answer available
How do you treat a Stage I endometrial squamous cell carcinoma?
MRI and cervical biopsy are negative for cervical involvement 
1 Answer available
Would you consider a single insertion HDR scheme for T&O brachytherapy (BID fractionation over 3 days)?
Would there be a substanital increase in the risk of toxicity using such a scheme?  We frequently have patients who have to travel long distance...
1 Answer available
What interventions besides lubricants do you advise to improve sexual satisfaction for patients s/p ChemoXRT for cervical cancer?
4 Answers available
What is optimal timing or sequencing of therapy for patients with synchronous locally advanced triple negative breast cancer and ovarian cancer with peritoneal carcinomatosis?
2 Answers available
For metastatic small cell cervix cancer, would you consider adding immunotherapy up front (per a small cell lung cancer paradigm)?
In December 2018, Horn et al reported the results of a phase 3 clinical trial in the NEJM (N Engl J Med 2018; 379:2220-2229). This trial included prev...
2 Answers available
Would focal clear cell features change your management for a grade 2 endometrial adenocarcinoma?
1 Answer available
Would you offer radiotherapy or chemotherapy a patient with cervical cancer s/p radical hysterectomy and now a delayed metastasis to the ovary that was completely resected without tumor spill?
The initial treatment did not include any adjuvant chemotherapy or radiation therapy.
2 Answers available
What is the maximum interval you would consider delivering adjuvant radiation therapy for endometrial cancer?
How long after hysterectomy would you consider delivering adjuvant radiation therapy? Would this differ for external beam versus brachytherapy? Are t...
1 Answer available
Do you recommend frontline bevacizumab with carbo/taxol in patients with advanced epithelial ovarian and BRCA mutation who will be receiving olaparib maintenance?
1 Answer available
In light of GOG-252, are there any situations where IP chemotherapy would be preferable following debulking of advanced epithelial ovarian cancer?
1 Answer available
When do you choose dose-dense chemotherapy v. q3 week therapy in advanced epithelial ovarian cancer?
1 Answer available
What is your preferred sequence of chemotherapy regimens after patients with metastatic endometrial cancer develop resistance to carboplatin + paclitaxel?
1 Answer available
Should women with adequately debulked ovarian cancer receive bevacizumab with chemotherapy in the adjuvant setting?
2 Answers available
How do you choose 1st line therapy for recurrent cervical cancer?
Would you be more or less likely to use a cisplatin-containing regimen if a patient had previously responded to chemoradiation with concurrent cisplat...
1 Answer available
How do you determine which systemic therapy to recommend in the 2nd line setting for metastatic, PD-L1 NEGATIVE cervical cancer?
1 Answer available
For a patient with vaginal adhesions/stenosis, do you recommend any other therapy besides a dilator?
Would estrogen cream be helpful in this scenario?
1 Answer available
Do you offer vaginal cuff brachy alone, vaginal cuff brachy and chemo, or WPRT for surgically staged IB grade 3 endometrial cancer?
Does the GOG 249 abstract guide you one way or the other?
2 Answers available
In vulvar cancer patients with a well lateralized primary s/p vulvectomyand ipsilateral LND meeting nodal-based criteria for adjuvant RT, would you consider RT to the ipsilateral groin and pelvis?
If so, are there any lymph node cut-offs you would have in terms of lymph node number or pathological ECE before you would add contralateral RT? What ...
1 Answer available
What dose and OAR constraints you use for boost with IMRT or SBRT when a patient with cancer of the cervix is not candidate for brachytherapy?
Could you discuss how you decide between IMRT or SBRT boost for a patient who is not able to receive intracavitary or interstitial HDR or LDR brachyth...
1 Answer available
Would you recommend EBRT/brachythrapy for any patients with stage III- IV uterine ca in light of GOG-258 data?
https://www.nejm.org/doi/full/10.1056/NEJMoa1813181
1 Answer available
Do you offer pelvic radiation for endometrial cancer with ITCs in the node(s) and no other high or intermediate risk factors?
1 Answer available
Do you continue Megestrol in a patient with inoperable endometrial cancer during definitive radiation therapy?
are there any positive or negative synergies from combined megestrol/RT treatment?
1 Answer available
How long would a vulvar cancer s/p definitive chemoradiotherapy, how long should the lesion be followed for regression before initiating biopsy or salvage surgery?
Should these patients be managed similar to p16 positive anal squamous cell carcinoma, and allowed six months or more for complete regression before c...
2 Answers available
Do you consider tumor mutation burden as a possible biomarker for response to immune checkpoint therapy in the second line setting for cervical cancer?
1 Answer available
How would you approach treatment for a primary carcinosarcoma of the cervix with pelvic and para-aortic nodal involvement?
What chemotherapy and sequencing with radiation therapy would you recommend? IS surgery a component of the treatment?
1 Answer available
Is pembrolizumab considered standard of care in the 2nd line treatment of recurrent cervical cancer?
Does the phase II KN-158 provide sufficient evidence to change management?
1 Answer available
Would you recommend 1st line pembrolizumab for PD-L1 positive recurrent/metastatic cervical cancer patient who is not a candidate for or refuses chemotherapy?
1 Answer available
When do you recommend PD-L1 testing for patients with recurrent cervical cancer?
Should this be done at the time of recurrence or after failure of 1st line therapy for recurrence?
1 Answer available
How do you manage maintenance therapy in BRCA wild type patients who have undergone primary surgery and achieved an optimal/complete gross resection?
With the recent publication of GOG252 - does this change your management for patients with ovarian cancer who undergo primary surgery who have an opti...
2 Answers available
What is your dose-fractionation for cylinder-based vaginal cuff HDR brachytherapy for an isolated vaginal cuff recurrence after whole pelvis EBRT with residual thickness of disease <5 mm?
What is your typical treatment depth prescribed to? What length of vaginal mucosa do you typically treat?
2 Answers available
In a pre-menopausal female with cervical cancer, would you boost a hypermetabolic ovary on PET?
Do you have an SUV cutoff for physiologic activity of the ovary?
1 Answer available
Would uterine perforation at the time of hysterectomy push you to recommend pelvic RT in a patient who would otherwise receive cuff brachytherapy?
1 Answer available
How do you typically prescribe dose to a PTV for standard IMRT plans?
3 Answers available
Do you typically recommend avoiding neupogen during radiation treatments?
5 Answers available
How do you decide when to offer post-operative adjuvant treatment for a stage IC1 ovarian granulosa cell tumor?
How does fertility preservation factor into your decision making?
2 Answers available
Do you give vaginal cuff brachytherapy or whole pelvis (or both), for patients with Stage III endometrial adenocarcinoma?
4 Answers available
What doses would you treat the primary and lymph nodes in node positive vulvar cancer patient with incidentally found focal SCC in a field of VIN3?
Surgeon is not planning vulvectomy, since biopsies showed 2 mm depth of invasion. Also tumor board felt dose to the primary site should be only about...
2 Answers available
Is there a benefit to EBRT for recurrent solitary fibrous tumor/ hemangiopericytoma in patient with multiple sites of intrapelvic recurrence?
In a patient, with multiple small volume lesions (5-25mm), would you offer pelvic RT?
1 Answer available
For stage IB1 cervical cancer s/p surgery with only 1 Sedlis criteria, should adjuvant pelvic EBRT or vaginal cuff brachytherapy be recommended in the presence of other adverse pathologic features, such as high tumor grade or very close but negative margins?
1 Answer available
Is obesity a risk factor for recurrence after definitive treatment for endometrial cancer?
At what point would you introduce the discussion of weight management, whether for risk reduction or overall health?
1 Answer available
Would you use different EBRT field edge for an HIV positive patient with FIGO IIIC1 (2018) cervical cancer with positive bilateral external iliac nodes?
Do you cover common iliac nodes (L3/L4) or keep field edge at L4/L5 to reduce bone marrow toxicity? 
1 Answer available
How do you decide on adjuvant therapy in a patient with a Stage IA uterine carcinosarcoma without any myometrial invasion?
The NCCN recommends either systemic therapy + brachytherapy or pelvic RT + brachy or brachy alone or observation. How do you decide among these option...
1 Answer available
How would you treat a patient with a FIGO G1 pT1bN0 endometrial adenoCA involving the lower uterine segment with >50% invasion and a separate focus of disease found involving the endocervical mucosa with no cervical stromal invasion?
The disease involving the endocervix was felt to be separate and appeared like a drop metastases
1 Answer available
Are you using the new FIGO 2018 staging or waiting until it is incorporated into the next AJCC edition?
4 Answers available
How do you manage refractory radiation cystitis status post pelvic EBRT/BT?
Specifically, is hyperbaric oxygen therapy (HBO) an effective treatment for refractory radiation cystitis?
1 Answer available
Do you recommend stopping olaratumab in patients receiving doxorubicin/olaratumab for treatment of advanced sarcoma?
Given the recent press release regarding the update on the phase 3 soft tissue sarcoma study of LARTRUVO (olaratumab) showing no benefit to the combin...
1 Answer available
For a patient with carcinosarcoma of the uterus and an allergic reaction to paclitaxel, would you have any reservations about using docetaxel instead?
1 Answer available
In light of the ongoing GOG 263 trial, do you consider adding concurrent chemo with RT for early stage cervical cancer as adjuvant after Rad Hyst off trial?
If so, what indications would you use other than Peters criteria?
1 Answer available
Now that there are three FDA-approved PARP inhibitors for use in ovarian cancer (niraparib, rucaparib, olaparib), how do you decide which one to use?
2 Answers available
Is it reasonable to only treat the inguinal nodes and not the pelvic nodes in an unresectable cT1cN0 vulvar SCC at the clitoris?
What would be factors that would indicate the need to include the pelvic nodes?
1 Answer available
How do you define and IR-CTV for cervical brachytherapy?
Do you use a trimmed 10 mm expansion on HR-CTV? Do you also include the entire initial extent of disease? How much does your IR-CTV coverage affect yo...
1 Answer available
Would you consider initiation of bevacizumab maintenance in a patient with primary ovarian cancer after optimal debulking surgery and standard carbo/taxol if they did not receive bevacizumab beginning with the carbo/taxol?
1 Answer available
How would you manage a localized stage IV squamous cell carcinoma of vagina involving the posterior vaginal wall and full thickness of the anterior rectal wall?
1 Answer available
What is the maximum time you would wait after hysterectomy to start RT for a FIGO II endometriod adenocarcinoma before cancelling treatment and saving for salvage?
1 Answer available
Should olaparib maintenance therapy be recommended in patients with BRCA-positive, advanced ovarian cancer after first line platinum-based chemotherapy?
Should this be the new standard of care based on the results from the recently published SOLO-1 trial?
1 Answer available
When do you refer a patient with metastatic ovarian cancer for upfront debulking v. neoadjuvant chemotherapy?
1 Answer available
How do you determine the choice of therapy for platinum resistant ovarian cancer in healthy, good performance status patients?
Two new phase 2 studies this year with apatinib/oral etoposide (AEROC) and sorafenib/topotecan (TRIAS) were released, and NCCN also lists many single ...
3 Answers available
What volumes would you use for salvage radiation in a patient with a pelvic lymph node recurrence of cervical cancer initially treated with surgery alone?
What dose would you use?
1 Answer available
What are the preferred treatment options for platinum resistant clear cell ovarian carcinoma?
1 Answer available
How do you treat endometrial cancer in the setting of a pCR after neoadjuvant chemotherapy?
Female in her 60s who had presented originally with well-differentiated endometrioid adeno clinically and radiographically involving bilateral paramet...
1 Answer available
How do you approach adjuvant therapy of serous intraepithelial carcinoma of the endometrium?
For a woman with complete resection of serous intraepithelial carcinoma of the endometrium, would you recommend adjuvant radiation or chemotherapy? Wh...
1 Answer available
What factors do you use to determine whether to add brachytherapy to EBRT for IIIC endometrial cancer?
Current NCCN guidelines suggest that vaginal brachytherapy is optional, and there may be concern for over-treatment locally given competing risk of di...
3 Answers available
Do you have any normal tissue constraints for endometrial cancer patients receiving EBRT and vaginal cuff brachytherapy?
1 Answer available
How do you match a para-aortic field to a previously irradiated whole pelvis field in a woman with PA nodal failure after definitive chemoRT for cervical cancer?
1 Answer available
How do you counsel a cervical cancer patient s/p definitive chemoRT who is not sexually active and refuses to use vaginal dilators to improve compliance?
2 Answers available
Do you add chemotherapy to pelvic radiation and brachytherapy for an isolated vaginal cuff recurrence of endometrial cancer?
3 Answers available
How would you treat an isolated port recurrence of an early stage cervical patient s/p WLE?
A literature search indicates that most port site recurrences are managed fairly aggressively with chemoRT or RT doses 45-66 Gy. This is understandabl...
1 Answer available
Do you recommend bevacizumab in platinum sensitive recurrences of epithelial ovarian cancer?
Or do you wait for platinum resistance?
1 Answer available
How do you sequence vaginal cuff brachytherapy with EBRT for post-op endometrial or cervical cases that require both modalities?
Sequentially or do you integrate the cuff brachy with the EBRT and if so what schedule, BIW, weekly, etc?
3 Answers available
In patients with recurrent advanced ovarian carcinoma and a hypersensitivity reaction to platinum, do you prefer a desensitization protocol to maximize response or switching to a non-platinum regimen?
1 Answer available
What approach have you found works best in treating persistent acute radiation proctitis in patients undergoing pelvic EBRT?
2 Answers available
How do you best manage bulky, clinical stage IIA squamous cell cancer of the cervical stump in a patient with a previous partial supra-cervical hysterectomy?
2 Answers available
How do you manage vaginal necrosis after pelvic radiation?
Hydrogen peroxide douches? Antibiotics? (If so, what are you covering?) When do you initiate hyperbaric oxygen? Do you find pentoxyfyline helpful? How...
1 Answer available
With vaginal cuff brachytherapy, do you treat to active or treatment length?
When you prescribe your dose at 0.5 cm depth of the vagina? For instance, if you measure a vaginal length to be 8 cm, would you prescribe to treat 4 c...
2 Answers available
How do you apply bolus and confirm daily air gaps/setup for vulvar cancer, especially for larger, fungating lesions?
1 Answer available
When do you consider neoadjuvant chemotherapy prior to definitive chemoradiation for cervical cancer?
Would organ invasion (bladder/rectum), size, feasibility of T&O, or size of nodes push you toward neoadjuvant chemotherapy?
2 Answers available
How would you treat a woman with an isolated vaginal cuff recurrence from endometrial cancer who has received salvage resection?
While EBRT + brachy may be preferred, what treatment would you offer if surgery has been performed? What dose and volume of EBRT, brachytherapy, or bo...
1 Answer available
How often do you believe para-aortic radiotherapy in addition to pelvic radiotherapy causes additional treatment breaks due to acute toxicity?
How do you weigh this concern with the need to prophylactically treat non-involved, high risk para-aortic lymphatics?
2 Answers available
How would you treat indeterminate non-PET avid sub-cm common iliac nodes in a patient with locally advanced cervical cancer?
How high would you extend your field? Would you treat differently if the patient had lower PET avid pelvic lymph nodes?
1 Answer available
When would you recommend surgical debulking of pelvic or para-aortic lymph nodes in cervical cancer prior to definitive chemoradiation therapy?
Do you use size criteria (i.e. bulky nodes over 3 cm), specific adverse histology (adenocarcinoma), or location (near small bowel), etc. 
2 Answers available
Is it safe and/or necessary to combine osimertinib and carboplatin/paclixel for a patient with stage IV EGFR mutated NSCLC and advanced ovarian carcinoma?
Certainly ovarian cancer will respond to carboplatin and paclitaxel and it sounds like a reasonable chemotherapy to give to a stage IV NSCLC, however ...
1 Answer available
Does size influence your decision making for women with low or low-intermediate risk endometrial cancer after hysterectomy?
More recent Italian (Sozzi et al) and French data (Canlorbe et al) show associations of greater tumor size > 25-35mm with higher rates of local &am...
1 Answer available
How do you manage vaginal dehiscence discovered during vaginal brachytherapy?
1 Answer available
What kidney dose constraints do you use for extended field radiation for cervical cancer using VMAT or IMRT?
1 Answer available
How would you manage a patient with a h/o HSIL & VAIN3 and recent colposcopic vaginal biopsies "highly concerning for exophytic pattern squamous cell carcinoma" refusing vaginectomy?
She has extensive colposcopic lesions at upper/mid vagina, but no palpable/visible lesions on standard pelvic exam. Pelvic MRI with 20cc US gel in vag...
1 Answer available
In light of PORTEC-3 and GOG 249 data, do you use adjuvant radiation therapy alone in stage Ib serous endometrial carcinoma?
PORTEC-3 assigned women with high risk stage I or stage II-III endometrial carcinoma to adjuvant external beam radiation vs adjuvant chemoradiation wi...
1 Answer available
Do you wait until a ureteral stent is placed to plan a locally advanced cervical cancer with hydronephrosis?
1 Answer available
What is your approach to an optimally debulked patient with Stage Ia FIGO gr 3 serous carcinoma of the ovary?
Is it reasonable to use single agent carboplatin for elderly patients?
2 Answers available
Are total abdominal radical hysterectomies preferred over laparoscopic hysterectomies in early cervical cancer?
Has your institution changed practice patters based on the findings of the LACC Trial (Pedro et al., SGO in 3/2018) showing worse outcomes with roboti...
1 Answer available
How do you approach endometrial cancer in the setting of multiple pelvic lymph nodes with ITCs and/or micromets, but no macrometastasis?
1 Answer available
How do you counsel/treat a locally advanced Stage IIB cervix cancer while patient is 12 weeks pregnant?
1 Answer available
Given criticism of GOG 88, and in light of various other recent data, would you deliver definitive XRT in place of inguinal lymph node dissection?
Would you deliver definitive RT in place of inguinal lymph node dissection in light of new data (PMID: 29336837) In the case of high risk but radiogr...
1 Answer available
What is the role of EBRT/brachytherapy (as an addition to chemotherapy) in the adjuvant management of optimally debulked stage IV uterine serous carcinoma?
NCCN guidelines mention EBRT/vaginal brachytherapy as options in addition to chemotherapy in the adjuvant setting for high grade histologies, stages 1...
1 Answer available
Do you routinely offer adjuvant whole pelvis and/or extended-field radiation therapy for lymph node-positive undifferentiated uterine sarcoma with positive pelvic and para-aortic lymph nodes, respectively, after complete surgical staging?
1 Answer available
When would you add an extra radiation dose to compensate for treatment breaks?
Apart from H&N SCC, are there times where adding an extra dose of radiation due to a tx break is appropriate?  Is there a decent equatio...
1 Answer available
What dose constraint(s) would you use for a patient with a pelvic kidney transplant getting pelvic RT?
1 Answer available
What is your management strategy for unresectable endometrial cancer due to gross cervical involvement with parametrial extension?
If the patient is responding to external beam and likely to be converted to resectable, what brachytherapy dose/fractionation do you prescribe and wha...
2 Answers available
How would you manage a patient with a subcentimeter stage I vaginal squamous cell carcinoma after a positive deep margin post local excision?
2 Answers available
How would you manage a short-interval (0-3 months) failure in the untreated para-aortic region after definitive treatment of locally advanced cervical cancer?
Assuming no distant metastases, should this scenario be managed with "sequential" chemoradiation to the para-aortic region with an external beam boost...
2 Answers available
How do you manage urgency and frequency of bowel movements secondary to radiation proctitis?
1 Answer available
How do you optimize HDR brachytherapy for intracavitary treatment of cervical cancer?
For HDR brachytherapy for cervical cancer do you use the dose optimization algorithm?  Is there a standard dwell time distribution that should be...
1 Answer available
Under what circumstance do you offer a definitive approach to local treatment of a patient with oligomestastatic cervical cancer found on initial staging PET/CT?
For example, assuming an excellent performance status, would you consider local radiation to the primary and metastasis in someone with a single ...
2 Answers available
How would you treat a patient who has an inguinal p16+ SCC lymph node of unknown origin?
Patient had a single 3cm node s/p  excisional biopsy of the one node without nodal dissection. We have done anoscopy and a thorough GYN exam...
2 Answers available
How do you approach boosting a distal vaginal tumor (residual thickness >5mm) abutting the rectum?
EBRT boost only? SBRT? If you recommend interstitial brachytherapy do you place needles freehand or with a template based approach?  
1 Answer available
What has been your institutional or personal experience with the Venezia or other hybrid interstitial brachytherapy applicators?
What have your liked or disliked about these newer applicators?
1 Answer available
Is further workup and management required for an incidentally found small focus of neuroendocrine tumor of the endometrium?
In a patient who underwent laparoscopy for endometriosis and was found to have a 1mm focus of neuroendocrine tumor, would you recommend further surger...
1 Answer available
Is radiation an appropriate alternative for a patient with multiply recurrent CIN 3 being considered for hysterectomy but unable to be medically optimized for surgery?
if so, would you favor brachytherapy alone? What dose?
1 Answer available
How does a sentinel lymph node biopsy versus nodal dissection affect your treatment decision for Stage II endometrial cancer?
What would be the appropriate treatment for grade I endometrial cancer s/p TAH/BSO but with SLNB yielding negative nodes. The uterus contained a 2cm t...
1 Answer available
How would you treat HGIL in a woman with a history of early stage endometrial cancer?
Assuming the early stage endometrial cancer was treated with TAH+BSO initially and no further treatment, what would your recommendations be for HGIL? ...
1 Answer available
Would you treat Vaginal intraepthelial neoplasia 3 with HDR brachytherapy?
 If so what dose/fractionation? This was reported here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918530/
2 Answers available
For metastatic and bulky locally recurrent carcinosarcoma, what palliative dose would you deliver to the pelvis for symptomatic control?
1 Answer available
What is your superior field (or CTV) border when treating para-aortic lymph nodes with extended field radiation therapy for endometrial cancer in the post-operative setting?
For women treated with IMRT, there are multiple ways to define the upper border of the field 1) contouring the PAs up to where the renal vessels exit...
1 Answer available
In what instances would you use bolus for locally advanced vulvar cancer using IMRT?
1 Answer available
What is the preferred second line agent for a woman with metastatic vulvar cancer who has progressed on carboplatin/paclitaxel?
She has metastatic disease beyond the pelvis (lungs).
2 Answers available
Have the presented results of GOG 249 at ASTRO 2017 changed management of early stage uterine papillary serous cancers from chemo +VC/EBRT to pelvic RT only?
Type II endometrial cancers made up roughly 15% of GOG 249 the study population, but seemed to be balanced between both arms.  Single institutio...
1 Answer available
What is the maximum dose to small bowel you would allow in a single fraction with gynecologic brachytherapy?
After whole pelvis radiation therapy, what would be the highest dose you would allow in a single fraction, versus the total course EQD2 for small bowe...
2 Answers available
Would you treat a uterine carcinosarcoma with omental spread with adjuvant whole abdominal radiation?
Would you consider this in a patient with a single omental metastasis found and no other distant spread after surgery?
2 Answers available
What palliative radiation dose would you give to a patient with vulvar cancer who has an inguinal recurrence in a field previously irradiated with 45 Gy?
1 Answer available
Would you consider BID treatment for a patient with a pelvic SCC (e.g. cervix or anal) if a significant amount of treatment days have been missed?
For example, a patient with cervical or anal SCC who has missed many treatments due to side effects, low blood counts, hospitalizations, or non-compli...
1 Answer available
Would you add a brachytheray boost to a locally advanced cervical cancer after surgical resection and pelvic RT?
What factors influence your decision? Does high grade histology or pathological stage play a role? If the patient received chemotherapy due to +LN, pa...
1 Answer available
What is your approach to a patient with locally advanced cervical cancer who presents with a fistula (rectal or bladder)?
Do you recommend upfront diversion? Are there unique planning considerations such as the inability to use bladder filling? How do you boost? What are ...
1 Answer available
Do you take patients off anticoagulation for tandem and ovoid or tandem and ring procedures?
1 Answer available
What is your approach to a cervical SCC patient in which you're unable to properly place a T&O, due to obliterated cervical os, after completion of EBRT?
Do you add an IMRT boost with possibly vaginal brachytherapy?
2 Answers available
What is your protocol for conscious sedation during T&O insertion?
What are your specific protocols for monitoring and for dosing narcotics and sedatives?
2 Answers available
Given the indication for rucaparib in ovarian cancer for both germline and somatic BRCA mutations, do you re-biopsy tissue at recurrence for a new somatic BRCA mutation?
1 Answer available
Are there instances where you prefer a SBRT boost rather than a brachytherapy boost when treating definitive locally advanced cervical cancer?
If so, what dose/ volume is prescribed? How do you account for motion?
1 Answer available
How do you plan urgent radiation therapy for vaginal bleeding caused by locally advanced cervical cancer?
What dose and technique do you use and how do you integrate the subsequent definitive treatment plan?
1 Answer available
Are there any situations in which you would offer brachytherapy alone instead of whole pelvis RT +/- brachytherapy for an endometrial cancer vaginal cuff recurrence?
2 Answers available
For a young patient with stage 4 endometrial cancer with an excellent response to anthracyclines, would you continue to give anthracyclines beyond the standard dosage cap if cardiac function remains normal by echocardiogram?
1 Answer available
When do you offer observation for resected stage II endometrial cancer?
In what situations is it appropriate to offer observation (rather than VBT) to patients with stage II endometrial carcinoma who have had a radical hys...
1 Answer available
How soon after pelvic RT can a routine colonoscopy be completed?
If a patient has a gynecological cancer, how long should one wait after RT before a screening colonoscopy can be completed?
1 Answer available
How would you manage a patient with low-volume non-invasive endometrioid carcinoma that is found in both the endometrium and ovary (pN0)?
Would you approach this situation as synchronous primaries (eg. FIGO IA in both) or as a locally advanced endometrial cancer (FIGO IIIA)? What adjuva...
2 Answers available
In your practice, what is your goal dose for boosting positive PA nodes in either the adjuvant or definitive treatment for cervical cancer?
Does definitive or adjuvant setting effect your planned dose?  For example, for a woman with IB2 cervical cancer status post hysterectomy, who wa...
1 Answer available
How would you approach the management of a patient with locally advanced cervical cancer as well as synchronous endometrial adenocarcinoma?
1 Answer available
When would a completion inguinofemoral node dissection followed by adjuvant RT (+/- chemo) be favored over definitive RT (+/- chemo) for SLN+ vulvar cancer?
1 Answer available
Do PORTEC-3 and GOG-258 change your approach to managing patients with high-risk or node positive endometrial cancer?
http://abstracts.asco.org/199/AbstView_199_180760.html http://abstracts.asco.org/199/AbstView_199_187537.html  
3 Answers available
What is your recommended radiation field for early stage vulvar cancer with persistent positive margins (T1a-T1b)?
When should pelvic/inguinal lymph nodes be included?
2 Answers available
What strategies have you found to be most helpful in improving patient compliance with vaginal dilator use after pelvic radiotherapy?
1 Answer available
How do you manage early stage I uterine serous carcinoma?
VC brachy, pelvic RT, +/- chemo?  Does your management change if it is confined to the endometrium without myometrium invasion or if it is only ...
2 Answers available
How do you approach bowel constraints in the setting of reirradiation?
Do you assume some recovery since the prior course of RT? If so, how much over what time period?
1 Answer available
How would you manage treatment of a cervical cancer in a patient unable to tolerate chemotherapy or an HDR boost due to medical commodities?
Would you utilize IMRT to provide a boost to gross disease? If so, how would you define your treatment volumes and what dose would try to achieve? Als...
3 Answers available
What situations do you use IMRT vs 4-field box technique (or visa versa) for patients with an intact cervix with no pelvic or para-aortic nodal involvement?
4 Answers available
How would you manage an endometrial cancer with no (or minimal) myometrial invasion and only a very small focus of disease in a pelvic node?
Would you still consider this high risk? If so, would you recommend pelvic radiation AND chemotherapy?
2 Answers available
Which chemotherapy regimen (if any) do you recommend for palliative concurrent chemoradiation for a symptomatic patient with metastatic cervical carcinoma and CKD stage 4 (GFR 15-29)?
1 Answer available
In what situations should chemotherapy be added to adjuvant radiation therapy in a resected vuvlar SCC?
Would you add chemotherapy if there was gross residual disease, pN+ and/or ECE?
2 Answers available
How would you treat small cell cancer of the cervix?
Can the classic indications for post-hysterectomy radiation (eg. "Sedlis" and "Peter's" criteria) be applied? Does the histology change radiation dose...
1 Answer available
When, if ever, would you consider adjuvant pelvic radiation after chemotherapy for a completely resected localized (Stage I - II) clear cell carcinoma of the ovary?
1 Answer available
What is the role of SBRT in recurrent oligometastatic ovarian cancer?
Is there evidence for SBRT for recurrent ovarian granulosa cell tumors? 
1 Answer available
How should a patient be treated when they have an isolated para-aortic recurrence after upfront chemotherapy and vaginal cuff brachytherapy for intermediate risk endometrioid endometrial adenocarcinoma?
If offering radiation therapy, would you treat extended field whole pelvis or just cover the para-aortic LNs with an involved field volume? Would your...
1 Answer available
How do you logistically give sandwich chemotherapy and whole pelvis radiation treatment in advanced endometrial cancer?
How many cycles do you prefer before and after? How long do you tend to wait before starting radiation after initial chemo and after radiation to resu...
1 Answer available
Which pathologic features do you use to determine VCB vs pelvic RT in Stage IA/IB endometrial patients in the era of Sentinal Lymph node Biopsy?
1 Answer available
At your institution how are cervical cancer patients managed who are intraoperatively found by frozen section to have positive pelvic lymph nodes?
What are the pros and cons of completing a simple hysterectomy versus aborting surgery followed by chemoRT?
1 Answer available
How do you sequence chemotherapy with radiotherapy for advanced endometrial cancer?
2 Answers available
In stage IIIC endometrial adenocarcinoma, does the finding of positive pelvic or para-aortic nodes after lymphadenectomy influence your whole pelvic dose?
2 Answers available
What dose/fractionation do you use when treating SCC of the vagina with vaginal cylinder brachytherapy after EBRT?
With stage I/II vaginal cancer and an excellent response to 4500cGy EBRT with <5mm residual thickness of tumor remaining, what is your dose/fractio...
1 Answer available
What is your approach to uterine perforation during the time of brachytherapy implant for cervical cancer?
When do you continue with treatment and when do you terminate the plan? What is your criteria? 
2 Answers available
When do you use a brachytherapy vaginal cuff boost in postoperative cervical cancer treatment?
Close but negative radial margins? LVSI?  What fractionation/dose do you use for your vaginal cuff boost if used? 
2 Answers available
Should presacral lymph nodes be included in a locally advanced endometrial cancer without cervical involvement with incomplete surgical staging (i.e. no lymph node dissection)?
Would your recommendations change based on stage? What factors would influence your decision to include presacral lymph nodes in a locally advanced en...
1 Answer available
What dose schedule do you prescribe to the HRCTV when using interstitial technique for treating cervical cancer with HDR brachytherapy?
Does this differ if the primary is vaginal? Do you prescribe the same dose when using an intracavitary applicator for cervix cancer? 
1 Answer available
How do approach palliation of local symptoms in the setting of metastatic vulvar cancer?
For palliation of vulvar cancer, what fractionation due you typically use.  Can some of the toxicity be avoided with a shorter course of treatmen...
1 Answer available
How do you approach the nodal treatment of vaginal cancer using IMRT or more specifically in what situations do you modify elective nodal coverage?
For instance, if you have anal canal involvement, do you cover the entire mesorectum?  Any other adjacent organ invasion that would lead to modif...
1 Answer available
When do you initiate vaginal cuff brachytherapy treatment after hysterectomy for early stage endometrial cancer?
Prior to starting vaginal cuff brachytherapy, do you wait for a specificed period of time prior to vaginal cuff brachy after hysterectomy?   Do y...
1 Answer available
How is your institution incorporating MRI planning into cervical EBRT/brachy?
With the results of the EMBRACE protocol, how do you approach MRI planning?  Do you plan with applicators in situ, or use preimplant (post EBRT) ...
2 Answers available
How do you manage moist desquamation when treating vulvar cancer?
Does this management depend on treatment site?
1 Answer available
What dose is required to gross disease in the definitive treatment of vulvar cancer?
For definitive vulvar ca, is 5940 cGy the minimum acceptable dose for gross disease? 5760cGy? Or should the dose be escalated beyond 60Gy?
2 Answers available
How do you approach treatment for isolated vaginal cuff recurrence of endometrial cancer in a patient previously treated with adjuvant vaginal cuff brachytherapy?
Does time since adjuvant cuff brachytherapy influence your radiotherapy approach, (for example 18 months vs 5 years)? Do you adjust your bladder/bowel...
1 Answer available
For what stages of primary vaginal cancer do you typically recommend concurrent chemotherapy with external beam radiation therapy?
1 Answer available
In what situations do you consider radiation to the pelvic and inguinal lymph nodes without treatment of the primary in vulvar cancer?
1 Answer available
Do you have any advice when utilizing palliative radiation therapy in patients currently being treated with a PARP inhibitor?
Can the drug continue during radiation therapy or should it be discontinued at a specified time prior to initiation of radiation?
1 Answer available
Do you ever alter dose/fractionation for early stage endometrial cancer patients receiving vaginal brachytherapy alone?
And if so, in which situations do you offer differing doses?
1 Answer available
In what situations do you consider adjuvant radiation for ovarian cancer?
For example, would you consider adjuvant chemotherapy alone to be sufficient in a patient with an isolated pelvic recurrence and positive margin after...
2 Answers available
What criteria do you use when choosing an applicator system for cervical brachytherapy patients?
For example, how do you decide between applicators such as tandem and ovoid versus tandem split ring insertion for cervical brachytherapy patients?&nb...
1 Answer available
Are there any situations where you would specifically not use IMRT/VMAT to treat post-operative gynecologic malignancies?
For instance, RTOG 0418 did not allow clear cell or papillary serous histologies, but subsequent trials that allow IMRT have (GOG 0249, 0258, RTOG 120...
1 Answer available
How do you boost patients with squamous cell carcinoma of the cervix or upper vagina with invasion of the posterior bladder?
Interstitial needles can result in hot spots in the bladder, but how well tolerated is that? On the other hand, intracavitary applicators usually don'...
1 Answer available
In the IMRT era, what role does brachytherapy play in the treatment of squamous cell carcinoma of the vulva?
1 Answer available
How does positive peritoneal washings factor into your treatment decisions regarding pelvic radiation and/or chemotherapy?
For example, in an otherwise intermediate risk localized endometrial cancer (Grade 2, FIGO IB)?
1 Answer available
How do you decide whether to treat proximal vs. entire vaginal cuff with intracavitary brachytherapy in early-stage endometrial adenocarcinoma?
What clinicopathologic features do you typically consider?
2 Answers available
What clinical and pathological factors guide your decision making when considering whether to recommend vaginal cuff brachytherapy following TAH/BSO for a FIGO stage IA or IB endometrial carcinoma?
2 Answers available
What pelvic fields do you treat for patients with FIGO IA2-IB cervical cancer patients who inadvertently get a simple hysterectomy but with lymph node sampling (for presumed endometrial carcinoma)?
In the setting of a negative lymph node sampling, would you treat a full pelvis or mini-pelvis to compensate for lack of the appropriate surgery? Is a...
1 Answer available
Do you recommend adjuvant pelvic RT for Stage 1 cervical adenocarcinoma?
In patients who don't meet traditional criteria for adjuvant chemoradiation from Peters (GOG 109) and < 2 high risk factors from Rotman (GOG 92) fo...
1 Answer available
Would you include a lymphocele in your IMRT treatment volumes for endometrial carcinoma?
If the post-operative simulation films reveal a significant lymphocele secondary to pelvic lymph node sampling, is it imperative that the entire lymph...
1 Answer available
For which patients with stage IA nonsurgically staged endometriod cancer would you add pelvic RT?
The gyn oncs at my institution sometimes will not perform lymphadenectomy if biopsy indicates low risk disease. Would LVSI as sole adverse risk factor...
1 Answer available
Do you treat inguinal lymph nodes for patients with low lying vaginal cancers?
Do you use SIB or sequential approach? Do size of lymph nodes influence your dose or decision?
4 Answers available
How do you manage early stage uterine carcinosarcoma?
Do you give cuff and chemo or pelvic CRT or chemo alone?
1 Answer available
Is there a role for elective para-aortic nodal irradiation in endometrial cancer?
Is there any indication for ENI in early stage disease or in advanced stages, without pathologic confirmation or PET positivity or CT size criteria?
1 Answer available
What is the optimal management of a pelvic sidewall recurrence of endometrial cancer in a patient who has not previously received radiation?
2 Answers available
What is your technique to calculate the vaginal surface dose in gyn intracavitary brachytherapy?
What exactly do you contour and what is your dose constraint to that volume?
4 Answers available
What is the role of parametrial and pelvic side wall boosts in the setting of volumetric brachytherapy for locally advanced cervical cancer treated with either 3DCRT or IMRT?
Does using something like a vienna applicator allow you to avoid dose escalation with more external beam? How do you recommend doing a classic pa...
2 Answers available
What are you posterior field borders for endometrial and cervical cancer 3DCRT plans?
Some classic references recommend the coverage of the entirety of the sacrum but the volume delineation guidelines for both seem to only cover the mos...
1 Answer available
Do the number of lymph nodes removed in a non-Stage IA/FIGO 1 endometrial cancer case, affect your decision for WPRT v. vaginal brachytherapy alone?
1 Answer available
When do you transfuse cervical cancer patients undergoing chemoradiation?
Do you try to keep Hb> 10 or 12? Or somewhere in between? 
1 Answer available
With vaginal cuff brachytherapy, do you treat to the surface or a depth and why?
1 Answer available
What is the appropriate dose for a patient with recurrent vulva VIN III?
The patient failed previous excisions and medical therapy and is no longer a surgical candidate.
1 Answer available
Once endometrial cancer recurs after no chemo or XRT, is it curative or palliative?
Does hydroureter and leg edema alter your opinion?
1 Answer available
What is the best treatment for a medically inoperable endometrial adenocarcinoma of the uterus FIGO 1, grade 1, type 1?
Brachytherapy, EBRT or both and what is the best dose?
1 Answer available
When is it appropriate to use adjuvant whole pelvis radiotherapy for Stage I endometrial adenocarcinoma?
1 Answer available
What is the likelihood of a successful pregnancy following pelvic irradiation?
How should we counsel young women who are receiving treatment for GI/GYN malignancies?
1 Answer available
How often should you re-plan interstitial brachytherapy for gynecologic malignancies?
Do you plan every fraction, every other fraction, or use one plan for the whole treatment?
1 Answer available
What is your strategy to deliver EBRT, brachytherapy, and a parametria/lymph node boost in less than 7-8 weeks for cervical cancer?
1 Answer available
What small bowel dose constraints do you use in gyn brachytherapy?
The most recent ABS guidelines don't discuss a dose constraint for the small bowel.
3 Answers available
After pelvic irradiation, how often do you recommend that female patients use a vaginal dilator and for how long?
What schedule is best for preventing fibrosis and for patient compliance?
1 Answer available
If a patient with locally advanced cervical cancer cannot receive brachytherapy following 45Gy to the whole pelvis, how do you optimally deliver your boost?
Does your strategy change if bladder invasion is present?
1 Answer available
What indications do you use to prophylactically treat para-aortic lymph nodes in cervical cancer?
Do you treat PAs if pelvic nodes are positive? If common iliacs are involved? Only if there are positive PA nodes?
2 Answers available
What instructions do you give patients to optimize bladder filling and rectal emptying for GU and GYN simulation and treatment?
1 Answer available
What dose constraint do you use for the female urethra in gynecologic brachytherapy?
Do the urethral constraints used in prostate brachytherapy apply to women undergoing gyn brachy?
1 Answer available
What lessons can we learn from RTOG 0418 in how to best use IMRT to treat endometrial cancer?
1 Answer available
What is the biggest mistake people make when using IMRT to treat cervical cancer?
1 Answer available


Papers discussed in this category

Gynecologic oncology, 2004-03
A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study.
Int. J. Radiat. Oncol. Biol. Phys., 2011-11-15
Fifteen-year radiotherapy outcomes of the randomized PORTEC-1 trial for endometrial carcinoma.
Lancet, 2010-03-06
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
Obstet Gynecol, 1980-10-01
Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients.
Lancet (London, England), 2009-01-10
Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis.
Int. J. Radiat. Oncol. Biol. Phys., 2005-08-01
Intravaginal high-dose-rate brachytherapy for stage I endometrial cancer: a randomized study of two dose-per-fraction levels.
Int. J. Radiat. Oncol. Biol. Phys., 1990-02-01
Postoperative vaginal irradiation with high dose rate afterloading technique in endometrial carcinoma stage I.
Brachytherapy, 2013
Urethral dosimetry and toxicity with high-dose-rate interstitial brachytherapy for vaginal cancer.
International journal of radiation oncology, biology, physics, 2011-02-01
Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the definitive treatment of cervix cancer.
Int J Radiat Oncol Biol Phys, 2013 Jul 9
Trends in the Utilization of Brachytherapy in Cervical Cancer in the United States.
Gynecologic oncology, 2003-12
Uterine papillary serous carcinoma (UPSC): a single institution review of 129 cases.
Int. J. Radiat. Oncol. Biol. Phys., 2014-05-01
Manifestation pattern of early-late vaginal morbidity after definitive radiation (chemo)therapy and image-guided adaptive brachytherapy for locally advanced cervical cancer: an analysis from the EMBRACE study.
Brachytherapy, 2015
Computed tomography planned interstitial brachytherapy for recurrent gynecologic cancer.
Gynecologic oncology, 2014-11
Neoadjuvant radiotherapy with or without chemotherapy followed by extrafascial hysterectomy for locally advanced endometrial cancer clinically extending to the cervix or parametria.
International journal of radiation oncology, biology, physics, 2018-08-01
Multi-institutional Analysis of Vaginal Brachytherapy Alone for Women With Stage II Endometrial Carcinoma.
Brachytherapy, 2019 Sep - Oct
Vaginal brachytherapy alone for patients with Stage II endometrial cancer with inner half cervical stromal invasion.
Gynecologic oncology, 2009-10
Node-positive adenocarcinoma of the endometrium: outcome and patterns of recurrence with and without external beam irradiation.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-01-01
Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study.
Gynecologic oncology, 2013-10
Risk-scoring system for the individualized prediction of lymphatic dissemination in patients with endometrioid endometrial cancer.
Gynecologic oncology, 2013-01
A multicenter evaluation of adjuvant therapy in women with optimally resected stage IIIC endometrial cancer.
Eur. J. Cancer, 2010 Jul 07
Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer--results from two randomised studies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-07-20
Phase III Trial: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer.
American journal of clinical oncology, 2015-06
Hemorrhagic radiation cystitis.
Curr Urol Rep, 2018 Apr 13
Scoping Review and Meta-analysis of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis.
Urology, 2016 Apr 25
Evaluation of Hyperbaric Oxygen Therapy in the Treatment of Radiation-induced Hemorrhagic Cystitis.
Urology, 2005-04
Early hyperbaric oxygen therapy improves outcome for radiation-induced hemorrhagic cystitis.
The Journal of urology, 1999-02
Hyperbaric oxygen therapy for radiation induced hemorrhagic cystitis.
Urol. Int., 2012 Jul 10
Hyperbaric oxygen therapy for radiation cystitis in patients with prostate cancer: a long-term follow-up study.
Gynecologic oncology, 2014-12
Adoption and impact of concurrent chemoradiation therapy for vaginal cancer: a National Cancer Data Base (NCDB) study.
Gynecologic oncology, 2013-08
Involved-field radiation therapy for locoregionally recurrent ovarian cancer.
J Clin Oncol, 2012 May 10
Low-stage ovarian clear cell carcinoma: population-based outcomes in British Columbia, Canada, with evidence for a survival benefit as a result of irradiation.
Ann. Oncol., 2011-02-01
Histotype predicts the curative potential of radiotherapy: the example of ovarian cancers.
Gynecologic oncology, 2010-03
The potential benefit of 6 vs. 3 cycles of chemotherapy in subsets of women with early-stage high-risk epithelial ovarian cancer: an exploratory analysis of a Gynecologic Oncology Group study.
Int. J. Radiat. Oncol. Biol. Phys., 2012 Aug 14
Curative chemoradiotherapy in patients with stage IVB cervical cancer presenting with paraortic and left supraclavicular lymph node metastases.
International journal of radiation oncology, biology, physics, 1994-07-30
Radical vulvectomy with postoperative irradiation for vulvar cancer: therapeutic implications of a central block.
Obstet Gynecol, 2009-09-01
Radiation therapy compared with pelvic node resection for node-positive vulvar cancer: a randomized controlled trial.
Radiother Oncol, 2015 24
Quality assurance in MR image guided adaptive brachytherapy for cervical cancer: Final results of the EMBRACE study dummy run.
Brachytherapy, 2012
American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part II: high-dose-rate brachytherapy.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2011-07
Should uterine tandem applicators ever be placed without ultrasound guidance? No: a brief report and review of the literature.
The Lancet. Oncology, 2017-03
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Gynecol. Oncol., 2008-11-01
Sparing fertility in young patients with endometrial cancer.
Eur. J. Cancer, 2016-09-01
Systemic review: Radiation therapy alone in medical non-operable endometrial carcinoma.
Gynecologic oncology, 2017-11
Image-guided tandem and cylinder brachytherapy as monotherapy for definitive treatment of inoperable endometrial carcinoma.
Brachytherapy, 2019 Apr 17
Magnetic resonance imaging response in patients treated with definitive radiation therapy for medically inoperable endometrial cancer-Does it predict treatment response?
Gynecologic oncology, 2004-04
Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence.
American journal of obstetrics and gynecology, 2010-10
Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients.
Obstetrics and gynecology, 1988-01
Surgically treated, early-stage neuroendocrine small-cell cervical carcinoma.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2014-11
Gynecologic Cancer InterGroup (GCIG) consensus review for small cell carcinoma of the cervix.
Gynecologic oncology, 2015-06
Impact of adjuvant chemotherapy with radiation for node-positive vulvar cancer: A National Cancer Data Base (NCDB) analysis.
International journal of radiation oncology, biology, physics, 2017-03-01
Bone Marrow-sparing Intensity Modulated Radiation Therapy With Concurrent Cisplatin For Stage IB-IVA Cervical Cancer: An International Multicenter Phase II Clinical Trial (INTERTECC-2).
Gynecologic oncology, 2006-10
Final analysis of RTOG 9708: adjuvant postoperative irradiation combined with cisplatin/paclitaxel chemotherapy following surgery for patients with high-risk endometrial cancer.
Gynecologic oncology, 2009-03
A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin with or without paclitaxel: A Gynecologic Oncology Group study.
Br. J. Cancer, 2006-08-07
Adjuvant chemotherapy vs radiotherapy in high-risk endometrial carcinoma: results of a randomised trial.
Gynecol. Oncol., 2009-07-01
Adjuvant carboplatin and paclitaxel chemotherapy interposed with involved field radiation for advanced endometrial cancer.
Medicine (Baltimore), 2015-04-01
Sequential chemotherapy and radiotherapy in the sandwich method for advanced endometrial cancer: a meta-analysis.
The Lancet. Oncology, 2017-09
Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial.
Cancer Nurs, 2017-04-21
Dilator Use After Vaginal Brachytherapy for Endometrial Cancer: A Randomized Feasibility and Adherence Study.
American journal of clinical oncology, 2018-08
Adjuvant External Radiation Impacts Outcome of Pelvis-limited Stage III Endometrial Carcinoma: A Multi-institutional Study.
Gynecologic oncology, 2014-12
Inguinal nodal region radiotherapy for vulvar cancer: are we missing the target again?
International journal of radiation oncology, biology, physics, 2005-12-01
Prevention of acute radiation-induced proctosigmoiditis by balsalazide: a randomized, double-blind, placebo controlled trial in prostate cancer patients.
Cancer, 1987-10-15
Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study.
Gynecologic oncology, 2015-09
Ovarian involvement in endometrioid adenocarcinoma of uterus.
Brachytherapy, 2016 Nov - Dec
Salvage high-dose-rate brachytherapy for isolated vaginal recurrence of endometrial cancer.
Radiother Oncol, 2016-09-01
Dose-volume effect relationships for late rectal morbidity in patients treated with chemoradiation and MRI-guided adaptive brachytherapy for locally advanced cervical cancer: Results from the prospective multicenter EMBRACE study.
International journal of radiation oncology, biology, physics, 2013-04-01
Preoperative intensity modulated radiation therapy and chemotherapy for locally advanced vulvar carcinoma: analysis of pattern of relapse.
International journal of radiation oncology, biology, physics, 2013-09-01
Are Radiation Therapy Oncology Group Para-aortic Contouring Guidelines for Pancreatic Neoplasm applicable to other malignancies--assessment of nodal distribution in gynecological malignancies.
Eur. J. Obstet. Gynecol. Reprod. Biol., 2015 Aug 22
Brachytherapy for vaginal intraepithelial neoplasia.
Cancer Res Treat, 2014 Jan 15
High-dose-rate brachytherapy for the treatment of vaginal intraepithelial neoplasia.
Gynecologic oncology, 2017-11
Outcomes of stage II endometrial cancer: The UPMC Hillman Cancer Center experience.
Curr Oncol Rep,
Pathology of Neuroendocrine Tumours of the Female Genital Tract.
Adv Anat Pathol,
Assigning site of origin in metastatic neuroendocrine neoplasms: a clinically significant application of diagnostic immunohistochemistry.
International journal of radiation oncology, biology, physics, 2005-05-01
Definitive radiation therapy for squamous cell carcinoma of the vagina.
International journal of radiation oncology, biology, physics, 1992
Groin dissection versus groin radiation in carcinoma of the vulva: a Gynecologic Oncology Group study.
Radiother Oncol, 2016 Apr 29
Image guided brachytherapy in locally advanced cervical cancer: Improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study.
Gynecologic oncology, 2014-05
Impact of post-radiation biopsies on development of fistulae in patients with cervical cancer.
N Engl J Med, 2016 Feb 25
Weekly vs. Every-3-Week Paclitaxel and Carboplatin for Ovarian Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-06-01
Randomized Trial of Intravenous Versus Intraperitoneal Chemotherapy Plus Bevacizumab in Advanced Ovarian Carcinoma: An NRG Oncology/Gynecologic Oncology Group Study.
The New England journal of medicine, 2011-12-29
Incorporation of bevacizumab in the primary treatment of ovarian cancer.
N Engl J Med, 2011 Dec 29
A phase 3 trial of bevacizumab in ovarian cancer.
International journal of radiation oncology, biology, physics, 2014-12-01
Extended field intensity modulated radiation therapy with concomitant boost for lymph node-positive cervical cancer: analysis of regional control and recurrence patterns in the positron emission tomography/computed tomography era.
Practical radiation oncology, 2015
Extended field intensity modulated radiation therapy for gynecologic cancers: Is the risk of duodenal toxicity high?
Curr Oncol Rep,
A critical overview of concurrent chemoradiotherapy in cervical cancer.
Cochrane Database Syst Rev,
Neoadjuvant chemotherapy for locally advanced cervix cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-06-10
OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer.
Lancet Oncol, 2017 Jun
Bevacizumab and paclitaxel-carboplatin chemotherapy and secondary cytoreduction in recurrent, platinum-sensitive ovarian cancer (NRG Oncology/Gynecologic Oncology Group study GOG-0213): a multicentre, open-label, randomised, phase 3 trial.
Lancet (London, England), 2017-10-28
Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial.
The New England journal of medicine, 2016-12-01
Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer.
The New England journal of medicine, 2012-04-12
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