Would you ever start radiation in the middle of cycle 1 of chemotherapy for LS-SCLC?
Or would you wait to start coincident with the start of cycle 2? If a shorter time from the start of any therapy to the end of radiation (SER) is significantly associated with improved survival, would it make sense to start radiation as soon as a plan is ready even if it is a few days or a week after starting cycle 1?
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How important is it to start RT on day 1 of a chemotherapy cycle?
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2 Answers
Mednet Member
Radiation Oncology · Yale School of Medicine
Answered on
The goal is to get RT started early in the course, and to maximize the concurrent part of the therapy. But of course a patient only gets chemo for a few days per cycle, and we don't know whether the ‘concurrent’ effect is entirely due to those days treatment, or whether the radio-sensitizing effect ...
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Mednet MemberInvited Expert
Medical Oncology · Roswell Park Comprehensive Cancer Center
Answered on
Answer to question is Yes! A randomized phase III trial from Korea by Sun et al showed that thoracic radiation on cycle 3 of chemotherapy was not inferior to early radiation based on OS, PFS and RR.
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