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Would you give transdermal hormone replacement therapy to a woman with remote history of provoked pulmonary embolism?

Is patch or gel HRT with ASA prophylaxis a reasonable option after counseling? Or do you add a prophylactic DOAC?
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Would you give transdermal hormone replacement therapy to a woman with remote history of provoked pulmonary embolism?

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1 Answer
Mednet Member
Mednet MemberInvited Expert
Hematology · Mayo Clinic
Answered on

There is good evidence that transdermal HRT does not pose the same risks as oral HRT (Morris and Talaulikar, PMID 36573625). ASA or DOAC prophylaxis is likely not indicated.

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