Would you introduce AR targeted therapy if a patient has already been successfully treated with LHRH for low risk, low volume metastatic hormone sensitive prostate cancer?
What is the time window in which you would consider adding AR targeted therapy?
Is there a time frame in which you would NOT consider introducing since the patient has already done well with LHRH alone?
2 Answers
Mednet MemberInvited Expert
Medical Oncology · University of Utah Huntsman Cancer Institute
Answered on
Most trials of novel AR targeted therapies, started the novel AR blockers within 3 to 6 months of starting standard androgen deprivation therapy. Hence, if that period has passed and the patient is doing well on standard Androgen deprivation therapy, I do not see a need to introduce a novel AR inhib...
Join for free or sign in to see the full answer
Mednet MemberInvited Expert
Medical Oncology · University of Virginia
Answered on
Although the time frame associated with the question "successfully treated" is not specified, the trials of the currently approved AR directed therapies abiraterone, apalutamide, and enzalutamide ranged from 3-6 months from the start of ADT for metastatic disease. Needless to say, the issue isn't wh...
Join for free or sign in to see the full answer