Would you manage a subtotally resected pilocytic astrocytoma with deleted CDKN2A differently than one with intact CDKN2A?
1 Answers
Mednet Member
Radiation Oncology · University of Arizona
Among brain tumors, CDKN2A loss has the greatest clinical implications in histologically low and intermediate grade gliomas. In IDH-mutant astrocytomas, the presence of homozygous deletion of CDKN2A is associated with poor outcome. Usually, pilocytic astrocytomas (grade 1) have a very good prognosis...