Would you offer a bone marrow biopsy to the patient with normal CBC and low MDS-associated mutation burden found on NGS?
E.g. TET2 mutation at < 10% allele frequency
Answer from: Medical Oncologist at Academic Institution
Generally speaking, we don't perform NGS sequencing for MDS-associated somatic mutations in individuals with normal blood counts. However, the issue does arise when cancer patients undergo blood-based sequencing for other reasons, for example. And, in the future, we may see more mutation testing in ...
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Medical Oncologist at The Center for Hematology and Oncology at Holy Cross Hospital Agree. Would not do it, marrow biopsy.
Agree. Would not do it, marrow biopsy.