Would you offer adjuvant systemic therapy for recurrent fallopian tube leiomyosarcoma after resection of an isolated liver metastasis that presented within 1 year from primary surgery?

If this was an R0 resection, then I would not offer adjuvant therapy. It would be beneficial to understand if this is a high-grade or a low-grade leiomyosarcoma and also the ER/PR status. If strongly positive, then perhaps maintenance aromatase inhibitor can be considered, however, there is no good dataset to support this approach.

In case, there is another recurrence in the future and this is again resectable, I would rather offer the AIM-75 regimen in the neoadjuvant setting prior to another ...