Would you offer concurrent chemoradiotherapy and/or adjuvant systemic therapy (chemo or immunotherapy) or for a completely resected stage III Merkel cell after WLE and ALND?

One would potentially extrapolate from the advanced/metastatic space that there would be a role for immunotherapy for patients with resected node + merkel cell. However, there is no clear data that support this approach. Majority of data looking at post operative systemic therapy + or - concurrent radiation have shown that concurrent therapy does not improve OS, and only one study showed potential benefit with concurrent therapy yet no benefit for chemotherapy alone. One could potentially use co...

I would recommend an adjuvant study like EA 6174 or any other adjuvant trial. Currently, the data to do anything for this patient is limiting and most individuals would watch and wait.