Would you offer concurrent chemoradiotherapy and/or adjuvant systemic therapy (chemo or immunotherapy) or for a completely resected stage III Merkel cell after WLE and ALND?
Patient is a 67yo with a pT1 (2.5mm) pN1a merkel cell of the chest, 1 mm deep, widely clear margins, SLN with 1.5mm met, 11 additional axillary lymph nodes negative.
2 Answers
Mednet Member
Medical Oncology · Sediman Cancer Center/University Hospitals of Cleveland Case Medical Center
Answered on
One would potentially extrapolate from the advanced/metastatic space that there would be a role for immunotherapy for patients with resected node + merkel cell. However, there is no clear data that support this approach. Majority of data looking at post operative systemic therapy + or - concurrent r...
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Mednet Member
Medical Oncology · University of Miami Sylvester Comprehensive Cancer Center
Answered on
I would recommend an adjuvant study like EA 6174 or any other adjuvant trial. Currently, the data to do anything for this patient is limiting and most individuals would watch and wait.
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