Would you offer consolidative full dose chemo-RT for local residual pancreatic disease in a patient with stage IV pancreatic adenocarcinoma with excellent response after induction chemotherapy?

I think radiotherapy can selectively be considered in patients like this.

The potential roles of radiation therapy could include:

1. Palliation of local symptoms. RT is very effective at palliating symptoms such as pain related to celiac plexus infiltration, etc. Lawrence et al., Journal of Clinical O...

Unfortunately, there is no data I'm aware of to support this type of approach. In the absence of data, the question is, what is the goal of treating this patient in this manner? I would typically favor a maintenance chemotherapy approach to minimize toxicity, rather than a consolidative approach. Re...