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Would you offer definitive XRT for muscle invasive bladder cancer arising within a bladder diverticulum?

For patients who are not surgical candidates and have MIBC involving a moderate to large bladder diverticulum, do you consider it safe to offer concurrent chemoradiation or radiotherapy alone? Is there a risk of bladder perforation?
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Would you offer definitive XRT for muscle invasive bladder cancer arising within a bladder diverticulum?

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2 Answers
Mednet Member
Mednet Member
Radiation Oncology · Stony Brook University School of Medicine
Answered on

A diverticulum is a common location for bladder cancer to arise. I am not aware of any association between RT diverticula and increased risk of bladder perforation. I have personally never had an issue treating diverticula to full dose (either 64 Gy in 2 Gy fractions or 55 Gy in 20 fractions) in ter...

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Mednet Member
Mednet Member
Radiation Oncology · Beth Israel Deaconess Medical Center/Harvard Medical School
Answered on

I don’t understand the question. There is no muscle in bladder diverticulum. So how can a patient have MIBC in a tick?

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