Would you offer endocrine therapy to a patient who developed a new contralateral pT1b pN0 ER/PR+ HER2- breast IDC 1 year after coming off 10 years of anastrozole for prior invasive breast cancer?

I would offer the patient endocrine therapy but would use a different endocrine agent than one the patient had been on for the previously diagnosed contralateral breast cancer. Since this patient was on anastrozole for 10 years (a non-steroidal aromatase inhibitor), I would probably choose a steroid...

Yes, absolutely - would offer endocrine therapy for this new ER/PR+ breast cancer that developed a year after stopping prior AI.