Would you offer hypofractionated radiation regimens for a young patient with glioblastoma with good performance status but travel concerns, making 6 weeks of radiation difficult?

I am not a neuro-radiation oncologist, but I must register my disagreement with Dr. @Dr. First Last answer. This is GBM. The cure rate is exceedingly low, no matter what the fractionation, age of the patient, PS, etc. We should work with the patient to maximize their remaining quality of life and no...

Hypofractionated regimens are best studied in the elderly. As a neuro-oncologist, I would not favor this for a young patient with good KPS, acknowledging the logistics/hardships which unfortunately affect so many of our patients. Also, some recurrent GBM clinical trials will exclude patients who did...

Glioblastoma carries a poor prognosis regardless of age, In the Stupp trial of 60 Gy in 6 weeks with concomitant and adjuvant temozolomide which enrolled patients between the ages of 18-70, the median survival was 14.6 months (95 percent confidence interval, 13.2 to 16.8) with radiotherapy plus temo...

I would agree that in a young patient with excellent KPS, I would strongly recommend 60 Gy/30 fractions and try to integrate social work at one's institution for assistance with travel or lodging.

If, for some reason, the patient would only be able to receive 3 weeks, even with the above, one could c...

I am a CNS radonc and physician scientist. There are Indian and Canadian small-scale RCTs that compared 60 Gy/20 vs 60 Gy/30 that are similar or trending towards better OS on the hazard ratio, and its SoC in those centers. And the convenience factor of being done in 4 weeks. But outside of that, no,...

I understand, as the others that support a longer course of treatment, that this is a nearly uniformly fatal disease.

The hypofractionation trial that everyone mentions that shows “no difference” has one data point that sways me. If you look at the survival table, at 30 months, there are 15 patients...