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Would you offer local therapy to a patient with GEJ adenocarcinoma with FDG-avid para-aortic node oligometastasis?

For nodes just inferior to the celiac/SMA axis and no other distant metastatic disease? Stage is formally M1, but just barely. The patient is otherwise reasonably healthy and in their 50s. Would you proceed with chemoRT +/- surgery?
2 Answers
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Radiation Oncology · Mayo Clinic School of Medicine
Answered on

I have favored induction systemic therapy and interval re-assessment. If responsive or at least stable disease, I have offered extended field CRT as long as the treatment volume seems reasonable and my perception is that it would be tolerable when assessed in the context of a patient’s performance s...

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Radiation Oncology · Fox Chase Cancer Center
Answered on

I agree with Dr. @Dr. First Last. We would typically start with 3-6 months of systemic therapy. This is less advanced disease than oligometastatic disease, and so I think it is appropriate to be aggressive. I haven't found that this particularly drives up toxicity, as that seems much more heavily im...

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