Would you offer OFS/AI alone or with the addition of chemotherapy in a premenopausal female with ER+/PR+ breast cancer with microscopic LN involvement and an OncoTypeDx score <11?

Oncotype recurrence score (RS) testing provides both prognostic and predictive information. This is a tumor with a low score and has an excellent prognosis, regardless of what treatment is given. Chemotherapy would not be necessary in an endocrine-sensitive tumor such as this.

The issue, of course, c...