Would you offer radiation for a plasmacytoma found on piecemeal endoscopic resection of an initially presumed nasal polyp if subsequent PET/CT was negative and no surgical margin status was known?

In general, unless an oncologic procedure was performed to address a solitary plasmacytoma, I would recommend a course of RT. For a lesion removed piecemeal, the risk of residual microscopic disease is quite high. As the lesion was small and only microscopic disease (presumably) remains, given the n...

I would offer radiotherapy in this situation in order to lower the risk of local relapse. A dose of 40-50 Gy would be adequate, I‘d likely give 23 x 2 Gy.

Will offer radiation 45 Gy at conventional fractionation