Would you offer radiation therapy for extramedullary testicular masses in the setting of multiple myeloma?

If a patient had a symptomatic plasmacytoma involving the testicle (which I don't think I have ever encountered), not responding to systemic therapy, palliative radiation therapy would be a reasonable modality. I would probably start with a very low dose and assess the response to therapy (2 Gy X 2)...

Testicular plasmacytoma is a rare entity with seventy-one cases published up to 2008. (Wang et al., PMID 18706213) The majority of these patients present as extramedullary manifestations of multiple myeloma. Testis involvement in myeloma and other hematological malignancies has been hypothesized to ...