Would you offer treatment according to the PROSPECT trial for rectal cancer in which an involved lymph node approaches the circumferential resection margin (CRM)?

Topics: Radiation Oncology • Gastrointestinal Cancers • Rectal Cancer

Consider a patient who prioritizes fertility preservation, for whom one of three suspicious nodes approaches the CRM, and is <1 mm from the mesorectal fascia (MRF).

Answer from: Radiation Oncologist at Academic Institution

Yes, if the goal is fertility preservation. One can start with Folfox chemotherapy and restage afterwards. If good response and the CRM is clear then proceed with surgery and if not, you can discuss doing chemoRT at that time.

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Radiation Oncologist at University of Nebraska Medical Center
This trial specifically enrolled patients with T2 ...

Answer from: Radiation Oncologist at Community Practice

Yes, I would consider chemo alone.Without knowing the exact T-stage and tumor characteristics, one cannot, for certain, know that this patient would fit the exact PROSPECT eligibility criteria.However, knowing the data does give us an option for some patients who would want to consider fertility pre...

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Radiation Oncologist at Washington University School of Medicine
For the record, this patient would not have been e...

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