Would you recommend adjuvant chemotherapy for a patient who achieved a CR after TNT for stage III rectal adenocarcinoma but underwent no initial surgery, and now has a local recurrence >12 months later with plans to undergo low-anterior resection?
Total neoadjuvant therapy (TNT) included FOLFOX x 4 months and concurrent chemo-RT
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What therapy would you offer a patient who initially received TNT for Stage 3 rectal adenocarcinoma and then had watch and wait approach, now s/p LAR for a local recurrence 1.5 years later?
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1 Answer
Mednet MemberInvited Expert
Medical Oncology · University of Wisconsin
Answered on
I wavered in my response to the poll, which tells me there is no clear "right" answer. The patient has had exposure to FOLFOX already, and assuming margins are negative, it is unclear if there is benefit to more chemo in this resection setting. I think you could apply the data we have for the lack o...
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