Given the relative dearth of data for radiotherapy in the management of T4 colon cancer, one of my residents, Dr. Chris McLaughlin just completed and published a SEER database analysis on this population of patients (McLaughlin et al. Radiother Oncol 2019).  He found that only about 5...

I do recommend post-operative RT with concurrent capecitabine for T4 tumors that invade the abdominal wall. I only cover the abdominal wall area at risk and treat to 50.4 Gy. For T4 tumors that invade other organs, I don't usually recommend radiation therapy except possibly in cases where the area a...

After an R1 resection of a T4 colon cancer, would not deliver postoperative chemo-radiation unless surgical clips had been placed to mark the area of positive margins and reconstruction had been performed to keep dose-limiting small bowel out of a post-op EBRT boost field.  If clips were placed...