Would you recommend changing a patient from the pill form of levothyroxine to Tirosint-SOL if they are started on a proton pump inhibitor?
Yue et al., PMID 38554774
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How do you manage levothyroxine therapy in a patient with hypothyroidism who is starting a PPI?
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1 Answer
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Endocrinology · Johns Hopkins Outpatient Endocrinology
Answered on
While it is true that PPI's may lead to a decrease in levothyroxine absorption due to decreased tablet dissolution in the stomach (Guzman-Prado et al., PMID 33469743), and that liquid formulations are not susceptible to this effect (Seng Yue et al., PMID 38554774), the decrease in levothyroxine abso...
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