Would you recommend PMRT for T2N0(i+) breast cancer?

If a patient was noted to have poorly differentiated histology with two tumor foci in the breast, positive LVSI, and isolated tumor cells in 1/3 sentinel nodes, would you offer PMRT with RNI?

3 Answers

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Radiation Oncology · Allegheny Health Network, Pittsburgh

Answered on

In this situation, I do not normally offer PMRT as long as margins are negative.

There are some that would consider in this scenario if triple negative but I don’t usually.

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Mednet Member

Radiation Oncology · University of Texas Health Science Center San Antonio MD Anderson Mays Cancer Center

Answered on · Updated on

Not routinely. Would consider discussion if young age and multiple other risk factors - TNBC, margin concern, dermal LVSI/involvement, or treatment response seen in the other nodes.

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Radiation Oncology · Icahn School of Medicine at Mount Sinai/Mount Sinai Hospital

Answered on

Hello. I have a similar patient in her late 20s with left breast T2N0(i+) IDC, central/retroareolar location, s/p bilateral TMs, L SLNBx, and tissue expander reconstruction. Pathology: T2 (3.6 cm) IDC, poorly differentiated, extensive-LVSI, anterior margin 1.5 mm, 0/6 LNs+ (2 LNs with ITCs). ER+ PR+...

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