Would you recommend switching from an integrase strand transfer inhibitor-based regimen to a different antiretroviral regimen, or would you instead add weight loss medications for a person with HIV experiencing weight gain that has not improved with lifestyle changes?

For a person with HIV on an integrase strand transfer inhibitor-based regimen experiencing weight gain that has not improved with lifestyle changes, what approach would you recommend?

• Switch from an integrase strand transfer inhibitor-based regimen to a different antiretroviral regimen
• Add weight loss medications like tesamorelin or GLP-1 receptor agonists
• Neither, and continue with the current INSTI-based regimen while focusing on other weight management strategies
• Other