Would you start neoadjuvant treatment with immunotherapy or BRAF/MEK inhibitors in a patient with a large regional inoperable BRAF V600E positive melanoma (IIIC)?

Topics: Melanoma/Skin Cancer • Medical Oncology

Answer from: Medical Oncologist at Community Practice

I prefer to start with BRAF inhibition, as the response rate is quite high, then ask the surgeon to complete the surgical resection after 3 to 6 months of therapy if the patient has a response, and usually offer adjuvant immunotherapy afterwards. If the patient does not respond, I would switch to i...

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Medical Oncologist at Yuma Regional Medical Center Cancer Center
How concerned are you with such switch therapy cau...

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