Would you treat primary small cell cancer of the trachea with spread to paratracheal lymph node any differently than a limited stage SCLC?

I would treat this the same as limited stage SCLC. This is not particularly common, though, in these settings, I do work closely with our interventional pulmonary team to preserve the airways while starting treatment, and maybe a situation to consider inpatient treatment for close monitoring, depend...

Extrapulmonary neuroendocrine tumors are rare, and may respond to “small cell treatment”, but have worse control, survival, and lack propensity for CNS metastasis, so no need to consider PCI.

As tracheal mucosa is exposed to more carcinogens, something seems to prevent oncogenesis there that is lack...