Would you treat Vaginal intraepthelial neoplasia 3 with HDR brachytherapy?

This is an option for persistent VAIN3 despite surgery and topical agent

I have treated with 6 Gy x5

Important principal is where you are presecribing dose. Previous HDR studies have shown high complications because entire length was treated to fixed depth of 5 mm or so. The vaginal wall thickness v...

Surgical resection is the treatment of choice for women with VAIN, but there are other acceptable approaches such as wide local excision, CO2 laser, electrocoagulation, and topical 5-FU. Vaginal brachytherapy has been described both using LDR and HDR techniques, and for the most part, with fairly po...