Would you use adjuvant hypofractionation (15-20 fractions) after BCT with negative margins for a patient with malignant phyllodes tumor?

We conventionally fractionate all our phyllodes patients given there is really no data currently (that I’m aware of) that supports hypofractionating this uncommon disease entity.

The Dartmouth-led series studied patients using conventionally fractionated radiation.

Barth Jr. et al. PMID 19424757

Their current clinical trial is studying partial breast radiation in Phyllodes using the B39 regimen.

NCT01089374

Although hypofractionation is essentially cemented for intact breast-only breast radiation fo...