Given the final publication of NSABP B-51, for which patients meeting trial eligibility would you still recommend regional nodal irradiation?  

This will generate varied responses. For the most part, I would not favor RT if pretreating imaging suggests 1-3 level 1 and 2 node only, targeted nodal biopsy done to document the clipped node removed, and pCR or major pathological response in the breast. Would consider if pretreatment information ...