Given the final publication of NSABP B-51, for which patients meeting trial eligibility would you still recommend regional nodal irradiation?
Answer from: Radiation Oncologist at Community Practice
The very first thing that should occur before one makes a decision about what they are going to do is to understand how the trial was designed and who was actually accrued to it. The first point is that B51 was a superiority and not a non-inferiority trial. A very related point to that is that they ...
Answer from: Radiation Oncologist at Academic Institution
Most foundational studies informing regional nodal management were conducted in the adjuvant setting, meaning that we had comparatively limited insight into the effectiveness of systemic therapy for an individual patient when deciding whether to offer RNI (or axillary surgery for that matter). NSABP...
Answer from: Radiation Oncologist at Community Practice
This will generate varied responses. For the most part, I would not favor RT if pretreating imaging suggests 1-3 level 1 and 2 node only, targeted nodal biopsy done to document the clipped node removed, and pCR or major pathological response in the breast. Would consider if pretreatment information ...
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Radiation Oncologist at Northside Hospital After reading the article, it is not clear why the...
Radiation Oncologist at START Center for Cancer Care Generally, I think that it is too early to change ...
Answer from: Radiation Oncologist at Community Practice
Great points discussed here!I couldn't agree more on the brilliant analysis by Dr. @Christina H. Chapman.Reading carefully through Dr. @Lior Braunstein's comments, I agree with many points discussed, and I think the results should be interpreted very cautiously in light of the very heterogeneous pop...
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Radiation Oncologist at Northside Hospital I appreciate all the valuable and informative inpu...
Radiation Oncologist at Hôtel Dieu de Lévis - CISSS Chaudière-Appalaches I'm not saying that systemic therapy has no effect...
Radiation Oncologist at START Center for Cancer Care @Tony Felefly, I totally agree, and we also need m...
Answer from: Radiation Oncologist at Community Practice
While I agree that it is reasonable to be cautious in the interpretation and the widespread application of the B51 results, it is also important to keep in mind that there is the potential to cause real harm to our patients with the addition of RNI. Balancing this risk against the possible benefits ...
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Radiation Oncologist at Comprehensive Cancer Centers of Nevada I have 2 patients now that I am treating with TNBC...
Radiation Oncologist at Baylor College of Medicine Department of Radiation Oncology Regarding the question of whether to omit radiatio...
Radiation Oncologist at Baylor College of Medicine Department of Radiation Oncology Re: Dr. @Anderson's point about seeing patien...